Endogenous Opioid Receptor Genes and Alcohol Dependence among Taiwanese Han

El Wui Loh, Cathy S.J. Fann, Yuh Terng Chang, Ching Jui Chang, Andrew T.A. Cheng

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Background: Nonselective opioid antagonists reduce alcohol consumption under various experimental situations, and several association studies have examined possible roles of opioid receptor mu (OPRM), delta (OPRD), and kappa (OPRK) genes in the development of alcohol dependence. Methods: We examined 20 single nucleotide polymorphisms (SNPs) across the OPRM, OPRD, and OPRK genes in 158 alcohol-dependent subjects and 149 controls. Differences in allele frequency and genotype distribution between case subjects and controls, as well as the deviation from Hardy-Weinberg equilibrium, were examined using Fisher's exact tests. Results: No significant difference in either allele or genotype frequency was found between case subjects and controls for each of the SNPs. Conclusions: Our findings do not support a possible role of the opioid receptor genes for the proclivity to alcohol dependence in the Taiwanese Han.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Issue number1
Publication statusPublished - Jan 2004
Externally publishedYes


  • Alcoholism
  • Association Study
  • Endogenous Opioid Receptor
  • Polymorphism

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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