Abstract
Rhodium-catalyzed enantioselective hydroacylation of racemic alkynals having a substituent at the α-position of the carbonyl group is described. This reaction can be applied for the wide range of substrates (22 examples), and mechanistic studies revealed that a dynamic kinetic resolution (DKR) process occurs during the hydroacylation, giving various cyclic ketones in 47–93% yields with 59:41 to 97:3 er from racemic starting materials.
| Original language | English |
|---|---|
| Pages (from-to) | 3432-3437 |
| Number of pages | 6 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 365 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - Oct 24 2023 |
Keywords
- Aldehyde
- Alkyne
- Cyclization
- Dynamic kinetic resolution
- Rhodium
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Enantioselective Intramolecular Hydroacylation of Alkynes by Rhodium Catalysis through Dynamic Kinetic Resolution'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS