TY - JOUR
T1 - Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene
AU - Su, Hsueh Yueh
AU - Cherng, Shur Hueih
AU - Chen, Chien Chung
AU - Lee, Huei
N1 - Funding Information:
This work was supportedb y grants from the National Science Council (NSC 84-2621-B-040-
PY - 1995/7
Y1 - 1995/7
N2 - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
AB - Polygonum cuspidatum S. (PC) is frequently used as a laxative and an anticancer drug in Chinese medicine. The inhibitory effect of this herb and its component, emodin, on the direct-acting mutagenicity of 1-nitropyrene (1-NP) was examined using the Ames/microsomal test with Salmonella typhimurium TA98 and the genotoxicity of 1-NP was evaluated using the SOS chromotest with E. coli PQ37. Emodin and water extracts of PC markedly decreased the mutagenicity of 1-NP in a dose-dependent manner in both assay systems. Furthermore, emodin and the extracts of PC significantly inhibited the formation of 1-NP DNA adducts in S. typhimurium TA98 in the 32P-postlabeling study. The results suggest that PC extracts and emodin act as blocking and/or suppressing agents to reduce the direct-acting mutagenicity of 1-NP.
KW - 1-Nitropyrene
KW - DNA adduct, Mutagenicity
KW - Emodin
KW - Polygonum cuspidatum S.
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U2 - 10.1016/0027-5107(95)00045-K
DO - 10.1016/0027-5107(95)00045-K
M3 - Article
C2 - 7603502
AN - SCOPUS:0029030412
SN - 0027-5107
VL - 329
SP - 205
EP - 212
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 2
ER -