Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

W. L. Yu; M. F. Lee; H. J. Tang; M. C. Chang; J. Walther-Rasmussen; Y. C. Chuang

doi:10.1016/j.cmi.2014.11.030

Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

W. L. Yu, M. F. Lee, H. J. Tang, M. C. Chang, J. Walther-Rasmussen, Y. C. Chuang

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We first describe two novel variants of bla_KPC, bla_KPC-16 and bla_KPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 bla_KPC-17-containing K.pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that bla_KPC-17-containing isolates can substantially threaten public health.

Original language	English
Pages (from-to)	347.e5-347.e8
Journal	Clinical Microbiology and Infection
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.cmi.2014.11.030
Publication status	Published - Apr 1 2015

Keywords

Carbapenemase
KPC-16
KPC-17
KPC-2
Klebsiella pneumoniae

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmi.2014.11.030

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title = "Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan",

abstract = "We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K.pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.",

keywords = "Carbapenemase, KPC-16, KPC-17, KPC-2, Klebsiella pneumoniae",

author = "Yu, {W. L.} and Lee, {M. F.} and Tang, {H. J.} and Chang, {M. C.} and J. Walther-Rasmussen and Chuang, {Y. C.}",

note = "Funding Information: This work was supported by grants from the Chi Mei Medical Centre Research Foundation, Taiwan ( CMFHT10202 and CMFHR10355 ), National Science Council, Executive Yuan, Taiwan ( NSC-100-2314-B-384-002 ) and Centers for Disease Control, Department of Health, Executive Yuan, Taiwan ( DOH102-DC-1508 ). Publisher Copyright: {\textcopyright} 2014 European Society of Clinical Microbiology and Infectious Diseases.",

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doi = "10.1016/j.cmi.2014.11.030",

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T1 - Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

AU - Yu, W. L.

AU - Lee, M. F.

AU - Tang, H. J.

AU - Chang, M. C.

AU - Walther-Rasmussen, J.

AU - Chuang, Y. C.

N1 - Funding Information: This work was supported by grants from the Chi Mei Medical Centre Research Foundation, Taiwan ( CMFHT10202 and CMFHR10355 ), National Science Council, Executive Yuan, Taiwan ( NSC-100-2314-B-384-002 ) and Centers for Disease Control, Department of Health, Executive Yuan, Taiwan ( DOH102-DC-1508 ). Publisher Copyright: © 2014 European Society of Clinical Microbiology and Infectious Diseases.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K.pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

AB - We first describe two novel variants of blaKPC, blaKPC-16 and blaKPC-17, which were identified in three Klebsiella pneumoniae isolates from a patient in Taiwan. KPC-16 and KPC-17 differed from KPC-2 by two (P202S and F207L) and a single (F207L) amino acid substitutions, respectively. All three isolates with identical pulsotype belonged to sequence type 11. The MICs of the three isolates for colistin and tigecycline were 0.5 μg/mL and 2 μg/mL, respectively. Moreover, an outbreak of at least 39 blaKPC-17-containing K.pneumoniae isolates is ongoing in southern Taiwan in 2014. Physicians should know that blaKPC-17-containing isolates can substantially threaten public health.

KW - Carbapenemase

KW - KPC-16

KW - KPC-17

KW - KPC-2

KW - Klebsiella pneumoniae

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Emergence of KPC new variants (KPC-16 and KPC-17) and ongoing outbreak in southern Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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