Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor

Chung Lan Kao, Shih Hwa Chiou, Donald Ming Tak Ho, Yann Jang Chen, Ren Shyan Liu, Chih Wen Lo, Fu Ting Tsai, Chi Hung Lin, Hung Hai Ku, Shang Ming Yu, Tai Tong Wong

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28 Citations (Scopus)


Osteopontin, a cancer metastasis-associated gene, is specifically up-regulated in central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT), but its biological behavior in the progression of CNS AT/RT has never been studied. We obtained plasma, cerebrospinal fluid (CSF), and brain tissue specimens from lobectomy of hemispherectomy samples from 39 patients (medulloblastoma, 16; AT/RT, 8; epilepsy, 6; hydrocephalus, 9). By enzyme-linked immunosorbent assay, the median osteopontin levels in plasma and CSF in AT/RT (852.0 and 1,175.0 ng/mL, respectively) were significantly higher than in medulloblastoma (492.5 and 524.5 ng/mL, respectively) and hydrocephalus and epilepsy (208.0 and 168.0 ng/mL, respectively) (P < .05). The results of real-time reverse transcriptase-polymerase chain reaction and immunohistochemical analysis demonstrated that osteopontin expression in AT/RT (n = 5) was significantly higher than in medulloblastoma (n = 8) samples. The differences in osteopontin expression in plasma, CSF, and tumor samples in AT/RT and medulloblastoma correlated with survival differences. In 5 patients with AT/RT, plasma osteopontin levels decreased after treatment but increased with relapse. Osteopontin might be a potential marker to aid in identifying AT/RT recurrence.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalAmerican Journal of Clinical Pathology
Issue number2
Publication statusPublished - Feb 2005
Externally publishedYes


  • Atypical teratoid/rhabdoid tumor
  • Medulloblastoma
  • Osteopontin
  • Primitive neuroectodermal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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