Elevated uric acid level as a significant predictor of chronic kidney disease: a cohort study with repeated measurements

Yu Ching Chou, Jen Chun Kuan, Tsan Yang, Wan Yun Chou, Po Chien Hsieh, Chyi-Huey Bai, San Lin You, Chien Hua Chen, Cheng Yu Wei, Chien An Sun

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Background: Cohort studies evaluating increased serum uric acid (SUA) level as a chronic kidney disease (CKD) risk factor have yielded variable results. We aimed to assess the association between the pattern of longitudinal changes in SUA and incident CKD [estimated glomerular filtration rate (eGFR) 2]. Methods: A population-based cohort study was conducted on 3,605 participants who were followed prospectively for a mean of 5.18 years. The longitudinal changes in SUA were categorized into three subgroups: persistently low, fluctuated (reduced or elevated), and persistently high. The primary outcome of interest was the development of CKD at a follow-up examination. Cox proportional hazards analysis was used to test the hypothesis. Results: After adjustment for potential confounders, participants with fluctuated SUA with progressively elevated level and persistently high SUA level had significantly higher risk of developing CKD compared to subjects with persistently low SUA level: adjusted hazard ratio (95 % confidence interval) was 2.05 (1.24–3.38) vs. 1.90 (1.34–2.71). This longitudinal relationship was independent of sex, age, body mass index, and hypertension status. Conclusions: Longitudinally elevated SUA independently predicts the risk of new-onset CKD.

Original languageEnglish
Pages (from-to)457-462
Number of pages6
JournalJournal of Nephrology
Issue number4
Publication statusPublished - Aug 23 2015


  • Chronic kidney disease
  • Cohort study
  • Uric acid

ASJC Scopus subject areas

  • Nephrology


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