Elevated nitric oxide levels in childhood brain tumors

Chung Lan Kao, Shih Hwa Chiou, Hong Shin Chen, Donald Ming Tak Ho, Chieh Fu Chen, Larry L.T. Ho, Meng Jer Lee, Tai Tong Wong

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objectives: One of the fundamental aspects of nitric oxide (NO) is the regulation of the inflammatory processes involved in neuronal apoptosis. Expressions of NO and NO synthase (NOS) are considered to be involved in brain tissue injuries and brain tumors. The purpose of our study was to investigate the roles of NO and inducible-form NOS (iNOS) in the pathogenesis of brain tumors. Methods: NO levels in the cerebrospinal fluid (CSF) of 36 brain tumor patients were detected utilizing the NO-chemiluminescence method. Deparaffinized tissue sections were immunostained for the presence of antibodies against iNOS and for apoptosis using the TUNEL stain. The results were compared with 10 control patients (with epilepsy and hydrocephalus). Conclusions: Higher levels of NO and iNOS activities may induce immune responses and neurotoxicities. This preliminary study revealed elevated NO and NOS activities with an increased amount of apoptotic processes in brain tumor tissues, which may indicate the possible roles of NO in the formation of brain tumors.

Original languageEnglish
Pages (from-to)744-749
Number of pages6
JournalChild's Nervous System
Issue number10-11
Publication statusPublished - Nov 2003
Externally publishedYes


  • Brain tumors
  • Cerebrospinal fluid
  • Epilepsy
  • Hydrocephalus
  • Nitric oxide
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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