Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

Yi Fang Tu; Chih Hao Lin; Hsueh Te Lee; Jing Jou Yan; Chun I. Sze; Ya Ping Chou; Chien Jung Ho; Chao Ching Huang

doi:10.1016/j.ijid.2015.03.017

Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

Yi Fang Tu, Chih Hao Lin, Hsueh Te Lee, Jing Jou Yan, Chun I. Sze, Ya Ping Chou, Chien Jung Ho, Chao Ching Huang

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p

Original language	English
Pages (from-to)	e105-e111
Journal	International Journal of Infectious Diseases
Volume	34
DOIs	https://doi.org/10.1016/j.ijid.2015.03.017
Publication status	Published - May 1 2015

Keywords

Encephalitis
Endothelin 1
Enterovirus 71
Neurogenic pulmonary edema

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijid.2015.03.017

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title = "Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis",

abstract = "Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p",

keywords = "Encephalitis, Endothelin 1, Enterovirus 71, Neurogenic pulmonary edema",

author = "Tu, {Yi Fang} and Lin, {Chih Hao} and Lee, {Hsueh Te} and Yan, {Jing Jou} and Sze, {Chun I.} and Chou, {Ya Ping} and Ho, {Chien Jung} and Huang, {Chao Ching}",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.ijid.2015.03.017",

language = "English",

volume = "34",

pages = "e105--e111",

journal = "International Journal of Infectious Diseases",

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TY - JOUR

T1 - Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

AU - Tu, Yi Fang

AU - Lin, Chih Hao

AU - Lee, Hsueh Te

AU - Yan, Jing Jou

AU - Sze, Chun I.

AU - Chou, Ya Ping

AU - Ho, Chien Jung

AU - Huang, Chao Ching

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p

AB - Objectives: Neurogenic pulmonary edema (NPE) is a fatal complication in children with enterovirus 71 (EV71) encephalitis. Endothelin 1 (ET-1), a potent vasoconstrictor, can induce pulmonary edema in rats via intrathecal injections. Thus, it was hypothesized that ET-1 in the central nervous system may correlate with NPE in children with EV71 encephalitis. Methods: Clinical data and ET-1 in the cerebrospinal fluid (CSF) were compared between three groups: (1) EV71 encephalitis with NPE; (2) EV71 encephalitis without NPE; and (3) non-EV71 aseptic meningitis. ET-1 immunostaining was performed on the brainstem of autopsy patients. Results: The EV71 with NPE group showed significantly increased CSF levels of ET-1 compared to the EV71 without NPE and the non-EV71 aseptic meningitis groups (both p

KW - Encephalitis

KW - Endothelin 1

KW - Enterovirus 71

KW - Neurogenic pulmonary edema

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Elevated cerebrospinal fluid endothelin 1 associated with neurogenic pulmonary edema in children with enterovirus 71 encephalitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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