TY - JOUR
T1 - Electrocardiographic features of failed and recurrent right ventricular outflow tract catheter ablation of idiopathic ventricular arrhythmias
AU - Yamada, Shinya
AU - Chung, Fa Po
AU - Lin, Yenn Jiang
AU - Chang, Shih Lin
AU - Lo, Li Wei
AU - Hu, Yu Feng
AU - Tuan, Ta Chuan
AU - Chao, Tze Fan
AU - Liao, Jo Nan
AU - Lin, Chung Hsing
AU - Lin, Chin Yu
AU - Chang, Yao Ting
AU - Chang, Ting Yung
AU - Te, Abigail Louise D.
AU - Chen, Shih Ann
N1 - Funding Information:
This work was supported by the Center for Dynamical Biomarkers and Translational Medicine, Ministry of Science and Technology (Grant No. MOST 106-2314-B-075-006-MY3, MOST104-2314-B-075-089-MY3, MOST 103-2911-I-008-001, MOST103-2314-B-075 -089 -MY3, NSC 102-2314-B-010-056-MY2), Research Foundation of Cardiovascular Medicine (Grant No. RFCM 104-01-012, RFCM 105-02-028, RFCM 105-02-008, and RFCM 105-02-028), TVGH-NTUH Joint Research Program (Grant No. VGHUST105-G7-4-1), Szu-Yuan Research Foundation of Internal Medicine (Grant No. 106003), TVGH-NTUH Joint Research Program (Grant No. VN103-04) and Taipei Veterans General Hospital (Grant No. V103C-042,
Funding Information:
This work was supported by the Center for Dynamical Biomarkers and Translational Medicine, Ministry of Science and Technology (Grant No. MOST 106-2314-B-075-006-MY3, MOST104-2314-B-075-089-MY3, MOST 103-2911-I-008-001, MOST103-2314-B-075 -089 -MY3, NSC 102-2314-B-010-056-MY2), Research Foundation of Cardiovascular Medicine (Grant No. RFCM 104-01-012, RFCM 105-02-028, RFCM 105-02-008, and RFCM 105-02-028), TVGH-NTUH Joint Research Program (Grant No. VGHUST105-G7-4-1), Szu-Yuan Research Foundation of Internal Medicine (Grant No. 106003), TVGH-NTUH Joint Research Program (Grant No. VN103-04) and Taipei Veterans General Hospital (Grant No. V103C-042, V104B-018, V104E7-001, V104C-109, V105B-014, V105C-122, V105C-116, V106C-158 and V106B-010).
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Introduction: Various ECG algorithms have been proposed to identify the origin of idiopathic outflow tract (OT)-ventricular arrhythmia (VA). However, electrocardiographic features of failed and recurrent right ventricular outflow tract (RVOT) ablation of idiopathic OT-VAs have not been clearly elucidated. Methods and results: A total of 264 consecutive patients (mean age: 44.0 ± 13.0 years, 96 male) undergoing RVOT ablation for OT-VAs with a transition ≥V3, including 241 patients (91.6%) with initially successful procedures and 23 patients (8.4%) with failed ablation. Detailed clinical characteristics and ECG features were analyzed and compared between the two groups. VAs with failed RVOT ablation had larger peak deflection index (PDI), longer V2 R wave duration (V2Rd), smaller V2 S wave amplitude, higher R/S ratio in V2, higher V3 R wave amplitude, and larger V2 transition ratio than those with successful ablation. Multivariate analysis demonstrated that PDI, V2Rd, V2 transition ratio, and pacemapping score acquired during mapping independently predicted failed ablation (P = 0.01, P = 0.01, P = 0.01, and P < 0.001, respectively). In 31 recurrent cases (12.8%) after initially successful ablation, multivariate Cox regression analysis showed that only the earliest activation time acquired during mapping predicted the recurrences after successful ablation (P = 0.001). The recurrent cases displayed different ECG features comparing with those with failed ablation. Conclusion: The electrocardiographic features of failed RVOT ablation of idiopathic OT-VAs with a transition ≥V3 were characterized by PDI, V2Rd, V2 transition ratio, and pacemapping score acquired during mapping, unlike the recurrent RVOT ablation.
AB - Introduction: Various ECG algorithms have been proposed to identify the origin of idiopathic outflow tract (OT)-ventricular arrhythmia (VA). However, electrocardiographic features of failed and recurrent right ventricular outflow tract (RVOT) ablation of idiopathic OT-VAs have not been clearly elucidated. Methods and results: A total of 264 consecutive patients (mean age: 44.0 ± 13.0 years, 96 male) undergoing RVOT ablation for OT-VAs with a transition ≥V3, including 241 patients (91.6%) with initially successful procedures and 23 patients (8.4%) with failed ablation. Detailed clinical characteristics and ECG features were analyzed and compared between the two groups. VAs with failed RVOT ablation had larger peak deflection index (PDI), longer V2 R wave duration (V2Rd), smaller V2 S wave amplitude, higher R/S ratio in V2, higher V3 R wave amplitude, and larger V2 transition ratio than those with successful ablation. Multivariate analysis demonstrated that PDI, V2Rd, V2 transition ratio, and pacemapping score acquired during mapping independently predicted failed ablation (P = 0.01, P = 0.01, P = 0.01, and P < 0.001, respectively). In 31 recurrent cases (12.8%) after initially successful ablation, multivariate Cox regression analysis showed that only the earliest activation time acquired during mapping predicted the recurrences after successful ablation (P = 0.001). The recurrent cases displayed different ECG features comparing with those with failed ablation. Conclusion: The electrocardiographic features of failed RVOT ablation of idiopathic OT-VAs with a transition ≥V3 were characterized by PDI, V2Rd, V2 transition ratio, and pacemapping score acquired during mapping, unlike the recurrent RVOT ablation.
KW - catheter ablation
KW - electrocardiography
KW - left ventricular outflow tract
KW - pacemapping score
KW - premature ventricular complex
KW - right ventricular outflow tract
KW - ventricular tachycardia
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U2 - 10.1111/jce.13359
DO - 10.1111/jce.13359
M3 - Article
C2 - 28988456
AN - SCOPUS:85032291753
SN - 1045-3873
VL - 29
SP - 127
EP - 137
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
IS - 1
ER -