Elastinolytic activity in the rat aortic smooth muscle cells in culture

Junko Nakao; Wen Chang Chang; Seiitsu Murota; Hajime Orimo

doi:10.1016/0021-9150(80)90246-4

Elastinolytic activity in the rat aortic smooth muscle cells in culture

Junko Nakao, Wen Chang Chang, Seiitsu Murota, Hajime Orimo

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Elastinolytic activity was examined in cultured rat aortic smooth muscle cells, using Congo Red elastin as a substrate. Elastinolytic activity was demonstrated in the soluble fraction of sonicated smooth muscle cells, with an optimal pH around 10.0. The soluble fraction also showed elastase-like esterolytic activity against the synthetic substrate, N-succinyl-trialanyl-paranitroanilide.

Original language	English
Pages (from-to)	539-544
Number of pages	6
Journal	Atherosclerosis
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/0021-9150(80)90246-4
Publication status	Published - 1980
Externally published	Yes

Keywords

Aortic smooth muscle cells
Elastase
Elastinolytic activity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0021-9150(80)90246-4

Cite this

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title = "Elastinolytic activity in the rat aortic smooth muscle cells in culture",

abstract = "Elastinolytic activity was examined in cultured rat aortic smooth muscle cells, using Congo Red elastin as a substrate. Elastinolytic activity was demonstrated in the soluble fraction of sonicated smooth muscle cells, with an optimal pH around 10.0. The soluble fraction also showed elastase-like esterolytic activity against the synthetic substrate, N-succinyl-trialanyl-paranitroanilide.",

keywords = "Aortic smooth muscle cells, Elastase, Elastinolytic activity",

author = "Junko Nakao and Chang, \{Wen Chang\} and Seiitsu Murota and Hajime Orimo",

year = "1980",

doi = "10.1016/0021-9150(80)90246-4",

language = "English",

volume = "36",

pages = "539--544",

journal = "Atherosclerosis",

issn = "0021-9150",

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TY - JOUR

T1 - Elastinolytic activity in the rat aortic smooth muscle cells in culture

AU - Nakao, Junko

AU - Chang, Wen Chang

AU - Murota, Seiitsu

AU - Orimo, Hajime

PY - 1980

Y1 - 1980

N2 - Elastinolytic activity was examined in cultured rat aortic smooth muscle cells, using Congo Red elastin as a substrate. Elastinolytic activity was demonstrated in the soluble fraction of sonicated smooth muscle cells, with an optimal pH around 10.0. The soluble fraction also showed elastase-like esterolytic activity against the synthetic substrate, N-succinyl-trialanyl-paranitroanilide.

AB - Elastinolytic activity was examined in cultured rat aortic smooth muscle cells, using Congo Red elastin as a substrate. Elastinolytic activity was demonstrated in the soluble fraction of sonicated smooth muscle cells, with an optimal pH around 10.0. The soluble fraction also showed elastase-like esterolytic activity against the synthetic substrate, N-succinyl-trialanyl-paranitroanilide.

KW - Aortic smooth muscle cells

KW - Elastase

KW - Elastinolytic activity

UR - https://www.scopus.com/pages/publications/0018876183

UR - https://www.scopus.com/inward/citedby.url?scp=0018876183&partnerID=8YFLogxK

U2 - 10.1016/0021-9150(80)90246-4

DO - 10.1016/0021-9150(80)90246-4

M3 - Article

C2 - 6903134

AN - SCOPUS:0018876183

SN - 0021-9150

VL - 36

SP - 539

EP - 544

JO - Atherosclerosis

JF - Atherosclerosis

IS - 4

ER -

Elastinolytic activity in the rat aortic smooth muscle cells in culture

Abstract

Keywords

ASJC Scopus subject areas

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