Elastinolytic activity in the rat aortic smooth muscle cells in culture

Junko Nakao, Wen Chang Chang, Seiitsu Murota, Hajime Orimo

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Elastinolytic activity was examined in cultured rat aortic smooth muscle cells, using Congo Red elastin as a substrate. Elastinolytic activity was demonstrated in the soluble fraction of sonicated smooth muscle cells, with an optimal pH around 10.0. The soluble fraction also showed elastase-like esterolytic activity against the synthetic substrate, N-succinyl-trialanyl-paranitroanilide.

Original languageEnglish
Pages (from-to)539-544
Number of pages6
Issue number4
Publication statusPublished - 1980
Externally publishedYes


  • Aortic smooth muscle cells
  • Elastase
  • Elastinolytic activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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