TY - JOUR
T1 - Eighteen-Year Follow-Up of a Retrospective Study of HLA Antibody on Kidney Graft Survival
AU - Lee, P. C.
AU - Ozawa, M.
AU - Hung, C. J.
AU - Lin, Y. J.
AU - Chang, S. S.
AU - Chou, T. C.
PY - 2009/1
Y1 - 2009/1
N2 - An increasing number of studies have demonstrated adverse graft survival in patients who have anti-HLA antibodies, whether preformed or developed posttransplantation. This retrospective study used Lambda antigen tray-mixed (LAT-M) screening and Luminex HLA class I and II specificity assay to re-examine the impact of pretransplantation HLA antibody on long-term graft survival. In this study, pretransplantation sera from 288 renal patients were tested using the enzyme-linked immunosorbent assay (ELISA) method, LAT-M. Among the 234 of the patients who did not have pretransplantation antibodies, 85% enjoyed 5-year functional graft survival, 76% 10-year functional graft survival, and 56% 15-year functional graft survival. The corresponding functional graft survival for the 54 patients who tested HLA antibody-positive was 65%, 53%, and 28%, respectively (P = .0021).
AB - An increasing number of studies have demonstrated adverse graft survival in patients who have anti-HLA antibodies, whether preformed or developed posttransplantation. This retrospective study used Lambda antigen tray-mixed (LAT-M) screening and Luminex HLA class I and II specificity assay to re-examine the impact of pretransplantation HLA antibody on long-term graft survival. In this study, pretransplantation sera from 288 renal patients were tested using the enzyme-linked immunosorbent assay (ELISA) method, LAT-M. Among the 234 of the patients who did not have pretransplantation antibodies, 85% enjoyed 5-year functional graft survival, 76% 10-year functional graft survival, and 56% 15-year functional graft survival. The corresponding functional graft survival for the 54 patients who tested HLA antibody-positive was 65%, 53%, and 28%, respectively (P = .0021).
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U2 - 10.1016/j.transproceed.2008.10.078
DO - 10.1016/j.transproceed.2008.10.078
M3 - Article
C2 - 19249493
AN - SCOPUS:60649086969
SN - 0041-1345
VL - 41
SP - 121
EP - 123
JO - Transplantation Proceedings
JF - Transplantation Proceedings
IS - 1
ER -