Abstract
Aim: Development of epigallocatechin gallate (EGCG) and gelatin-doxorubicin conjugate (GLT-DOX)-coated gold nanoparticles (DOX-GLT/EGCG AuNPs) for fluorescence imaging and inhibition of prostate cancer cell growth. Materials & methods: AuNPs alternatively coated with EGCG and DOX-GLT conjugates were prepared by a layer-by-layer assembly method. The physicochemical properties of the AuNPs and the effect of Laminin 67R receptor-mediated endocytosis on the anticancer efficacy of the AuNPs were examined. Results: The AuNPs significantly inhibit the proliferation of PC-3 cancer cell and the enzyme-responsive intracellular release of DOX could be tracked by monitoring the recovery of the fluorescence signal of DOX. Conclusion: Laminin 67R receptor-mediated delivery of DOX using the AuNPs enhanced cellular uptake of DOX and improved apoptosis of PC-3 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 9-30 |
| Number of pages | 22 |
| Journal | Nanomedicine |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2016 |
Keywords
- EGCG
- Lam 67R
- MMP-2
- cellular uptake
- doxorubicin
- drug release
- gelatin
- gold nanoparticles
- prostate cancer
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
- General Materials Science
- Medicine (miscellaneous)
