Efficacy of 5% dextrose water injection for peripheral entrapment neuropathy: A narrative review

Yung Tsan Wu, Chueh Hung Wu, Jui An Lin, Daniel Chiung Jui Su, Chen Yu Hung, Stanley K.H. Lam

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Current non-surgical treatment for peripheral entrapment neuropathy is considered in-significant and unsustainable; thus, it is essential to find an alternative novel treatment. The technique of perineural injection therapy using 5% dextrose water has been progressively used to treat many peripheral entrapment neuropathies and has been proven to have outstanding effects in a few high-quality studies. Currently, the twentieth edition of Harrison’s Principles of Internal Medicine textbook recommends this novel injection therapy as an alternative local treatment for carpal tunnel syndrome (CTS). Hence, this novel approach has become the mainstream method for treating CTS, and other studies have revealed its clinical benefit for other peripheral entrapment neuropathies. In this narrative review, we aimed to provide an insight into this treatment method and summarize the current studies on cases of peripheral entrapment neuropathy treated by this method.

Original languageEnglish
Article number12358
JournalInternational journal of molecular sciences
Issue number22
Publication statusPublished - Nov 1 2021


  • 5% dextrose
  • Carpal tunnel syndrome
  • Entrapment nerve
  • Hydrodis-section
  • Ultrasound-guided

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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