Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats

K. W. Chang; M. C. Lin; S. Y. Lee; H. Y. Chen; C. C. Chen; Y. K. Fu

doi:10.1016/j.apradiso.2012.06.024

Effects of [ ¹²³I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats

K. W. Chang, M. C. Lin, S. Y. Lee, H. Y. Chen, C. C. Chen, Y. K. Fu

Research output: Contribution to journal › Article › peer-review

Abstract

Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ ¹²³I]ADAM ([ ¹²³I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ ¹²³I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ ¹²³I]ADAM was not toxic in an animal pregnancy model.

Original language	English
Pages (from-to)	2646-2651
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	11
DOIs	https://doi.org/10.1016/j.apradiso.2012.06.024
Publication status	Published - Nov 1 2012
Externally published	Yes

Keywords

ADAM
Animal pregnancy model
Depression
Toxicity

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2012.06.024

Cite this

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title = "Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats",

abstract = "Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ 123I]ADAM ([ 123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ 123I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ 123I]ADAM was not toxic in an animal pregnancy model.",

keywords = "ADAM, Animal pregnancy model, Depression, Toxicity",

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AU - Chang, K. W.

AU - Lin, M. C.

AU - Lee, S. Y.

AU - Chen, H. Y.

AU - Chen, C. C.

AU - Fu, Y. K.

PY - 2012/11/1

Y1 - 2012/11/1

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AB - Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ 123I]ADAM ([ 123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ 123I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ 123I]ADAM was not toxic in an animal pregnancy model.

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KW - Animal pregnancy model

KW - Depression

KW - Toxicity

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