Effects of probiotics supplementation on skin photoaging and skin barrier function: A systematic review and meta-analysis

Jhen Yu Jwo, Ya Ting Chang, Yu Chen Huang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: Ultraviolet (UV) irradiation is one of the major causes of skin aging. To date, there remains limited evidence on using oral probiotics for skin anti-photoaging. Objectives: This systematic review and meta-analysis aims to assess the effects of probiotics on skin photoaging. Methods: We searched the PubMed and Embase databases for studies published until August 31, 2021, and included randomized controlled trials, murine randomized controlled experiments, and in vitro studies. Skin barrier function was compared between UV irradiated probiotics and controls. Results: After given oral probiotics supplements, a significant reduction was shown in all types of measured MMPs in both murine and in vitro studies. Oral probiotics supplementation significantly reversed UV-induced increase of epidermal thickness (standardized mean differences [SMD] = −1.76; 95% confidence interval [CI] = −3.04 to −0.49; p =.007; I2 = 81%), UV-induced increase trans-epidermal water loss (SMD = −1.72; 95% CI = −2.76 to −0.67; p =.001; I2 = 57%), and UV-induced skin dehydration (SMD = 1.85; 95% CI = 1.16 to 2.55; p <.00001; I2 = 4%). Conclusions: Probiotics are effective against skin photoaging in terms of MMP pathways and reversing skin barrier function from murine randomized data. Further randomized controlled trials on humans are required to warrant these results.

Original languageEnglish
Pages (from-to)122-131
Number of pages10
JournalPhotodermatology Photoimmunology and Photomedicine
Issue number2
Publication statusPublished - Mar 2023


  • meta-analysis
  • probiotics
  • skin photoaging
  • systematic review
  • ultraviolet

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Radiology Nuclear Medicine and imaging
  • Dermatology


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