TY - JOUR
T1 - Effects of preoperative oral carbohydrate on postoperative discomfort in patients undergoing elective surgery
T2 - a meta-analysis of randomized controlled trials
AU - Cheng, Po Lung
AU - Loh, El Wui
AU - Chen, Jui Tai
AU - Tam, Ka Wai
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Purpose: Fasting is a standard preoperative procedure performed to prevent vomiting and pulmonary aspiration during anaesthesia and surgery. However, fasting can cause postoperative physical and psychological discomfort. Intake of oral carbohydrate (CHO) may mimic the intake of food, which prevents postoperative discomfort. We conducted a meta-analysis to evaluate the effect and safety of preoperative oral CHO in adult surgical patients. Methods: Randomized controlled trials (RCTs) were searched for in the PubMed, EMBASE, and Cochrane Library databases. A meta-analysis was performed to calculate a pooled effect size by using random-effects models. The satisfaction outcomes were mouth dryness, hunger, thirst, pain severity, duration of hospitalization, homeostatic model assessment for insulin resistance (HOMA-IR), and the incidence of postoperative nausea and vomiting. The safety outcomes were the incidence of aspiration and infection. Results: In total, 57 RCTs involving 5606 patients were included. The outcomes of mouth dryness, thirst, hunger, and pain were assessed by a 10-point visual analogue scale (0 = best, 10 = worst). The severity of mouth dryness (weighted mean difference [WMD]: −1.26, 95% CI: −2.36 to −0.15), thirst (WMD: −1.36, 95% CI: −2.05 to −0.67), hunger (WMD: −1.66, 95% CI: −2.53 to −0.80), pain (WMD: −0.68, 95% CI: −1.01 to −0.35), duration of hospitalization (WMD: −0.39 day, 95% CI: −0.66 to −0.12), and HOMA-IR (WMD: −1.80, 95% CI: −2.84 to −0.76) were significantly lower in the CHO group than in the control group. The incidence of postoperative nausea and vomiting did not differ between the CHO and control groups. No aspiration was recorded in any of the groups. Conclusions: Preoperative CHO can alleviate patient’s discomfort without safety concerns. Surgeons and anaesthesiologists should strongly promote preoperative CHO as a strategy to enhance recovery after surgery protocols.
AB - Purpose: Fasting is a standard preoperative procedure performed to prevent vomiting and pulmonary aspiration during anaesthesia and surgery. However, fasting can cause postoperative physical and psychological discomfort. Intake of oral carbohydrate (CHO) may mimic the intake of food, which prevents postoperative discomfort. We conducted a meta-analysis to evaluate the effect and safety of preoperative oral CHO in adult surgical patients. Methods: Randomized controlled trials (RCTs) were searched for in the PubMed, EMBASE, and Cochrane Library databases. A meta-analysis was performed to calculate a pooled effect size by using random-effects models. The satisfaction outcomes were mouth dryness, hunger, thirst, pain severity, duration of hospitalization, homeostatic model assessment for insulin resistance (HOMA-IR), and the incidence of postoperative nausea and vomiting. The safety outcomes were the incidence of aspiration and infection. Results: In total, 57 RCTs involving 5606 patients were included. The outcomes of mouth dryness, thirst, hunger, and pain were assessed by a 10-point visual analogue scale (0 = best, 10 = worst). The severity of mouth dryness (weighted mean difference [WMD]: −1.26, 95% CI: −2.36 to −0.15), thirst (WMD: −1.36, 95% CI: −2.05 to −0.67), hunger (WMD: −1.66, 95% CI: −2.53 to −0.80), pain (WMD: −0.68, 95% CI: −1.01 to −0.35), duration of hospitalization (WMD: −0.39 day, 95% CI: −0.66 to −0.12), and HOMA-IR (WMD: −1.80, 95% CI: −2.84 to −0.76) were significantly lower in the CHO group than in the control group. The incidence of postoperative nausea and vomiting did not differ between the CHO and control groups. No aspiration was recorded in any of the groups. Conclusions: Preoperative CHO can alleviate patient’s discomfort without safety concerns. Surgeons and anaesthesiologists should strongly promote preoperative CHO as a strategy to enhance recovery after surgery protocols.
KW - Anaesthesia
KW - Fasting
KW - Operation
KW - Oral carbohydrate
KW - Perioperative
KW - Safety
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U2 - 10.1007/s00423-021-02110-2
DO - 10.1007/s00423-021-02110-2
M3 - Article
AN - SCOPUS:85101587280
SN - 1435-2443
VL - 406
SP - 993
EP - 1005
JO - Langenbeck's Archives of Surgery
JF - Langenbeck's Archives of Surgery
IS - 4
ER -