Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Szu Yu Pu; Ya Li Huang; Chi Ming Pu; Yi No Kang; Khanh Dinh Hoang; Kee Hsin Chen; Chiehfeng Chen

doi:10.3390/nu15092080

Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Szu Yu Pu, Ya Li Huang, Chi Ming Pu, Yi No Kang, Khanh Dinh Hoang, Kee Hsin Chen, Chiehfeng Chen

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (p = 0.21) of collagen or corresponding measurements (p = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.

Original language	English
Article number	2080
Journal	Nutrients
Volume	15
Issue number	9
DOIs	https://doi.org/10.3390/nu15092080
Publication status	Published - May 2023

Keywords

anti-aging
meta-analysis
oral collagen
skin
systematic review

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics

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10.3390/nu15092080

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title = "Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis",

abstract = "This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (p = 0.21) of collagen or corresponding measurements (p = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.",

keywords = "anti-aging, meta-analysis, oral collagen, skin, systematic review",

author = "Pu, {Szu Yu} and Huang, {Ya Li} and Pu, {Chi Ming} and Kang, {Yi No} and Hoang, {Khanh Dinh} and Chen, {Kee Hsin} and Chiehfeng Chen",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = may,

doi = "10.3390/nu15092080",

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volume = "15",

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T2 - A Systematic Review and Meta-Analysis

AU - Pu, Szu Yu

AU - Huang, Ya Li

AU - Pu, Chi Ming

AU - Kang, Yi No

AU - Hoang, Khanh Dinh

AU - Chen, Kee Hsin

AU - Chen, Chiehfeng

PY - 2023/5

Y1 - 2023/5

N2 - This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (p = 0.21) of collagen or corresponding measurements (p = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.

AB - This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (p = 0.21) of collagen or corresponding measurements (p = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.

KW - anti-aging

KW - meta-analysis

KW - oral collagen

KW - skin

KW - systematic review

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Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Abstract

Keywords

ASJC Scopus subject areas

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