Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

Original languageEnglish
Pages (from-to)9274-9279
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Issue number19
Publication statusPublished - 2009


  • Dioscorin
  • Immunomodulatory
  • Mucosal
  • Yam

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Chemistry


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