Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses

Yen Wenn Liu; J. U Chi Liu; Chun Yao Huang; Chung Kwe Wang; Huey Fang Shang; Wen Chi Hou

doi:10.1021/jf902245k

Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses

Yen Wenn Liu, J. U Chi Liu, Chun Yao Huang, Chung Kwe Wang, Huey Fang Shang, Wen Chi Hou

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49⁺) and/or B cells (CD19⁺), elevated the phagocytosis of PMN (p

Original language	English
Pages (from-to)	9274-9279
Number of pages	6
Journal	Journal of Agricultural and Food Chemistry
Volume	57
Issue number	19
DOIs	https://doi.org/10.1021/jf902245k
Publication status	Published - 2009

Keywords

Dioscorin
Immunomodulatory
Mucosal
Yam

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Chemistry(all)

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10.1021/jf902245k

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title = "Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses",

abstract = "Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p",

keywords = "Dioscorin, Immunomodulatory, Mucosal, Yam",

author = "Liu, {Yen Wenn} and Liu, {J. U Chi} and Huang, {Chun Yao} and Wang, {Chung Kwe} and Shang, {Huey Fang} and Hou, {Wen Chi}",

year = "2009",

doi = "10.1021/jf902245k",

language = "English",

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journal = "Journal of Agricultural and Food Chemistry",

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AU - Liu, Yen Wenn

AU - Liu, J. U Chi

AU - Huang, Chun Yao

AU - Wang, Chung Kwe

AU - Shang, Huey Fang

AU - Hou, Wen Chi

PY - 2009

Y1 - 2009

N2 - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

AB - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

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KW - Immunomodulatory

KW - Mucosal

KW - Yam

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Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses

Abstract

Keywords

ASJC Scopus subject areas

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