TY - JOUR
T1 - Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities
AU - Lin, Yin Shiou
AU - Chen, Sheng-Hsuan
AU - Huang, Wei Jan
AU - Chen, Chao Hsiang
AU - Chien, Mei Yin
AU - Lin, Shyr Yi
AU - Hou, Wen Chi
N1 - Funding Information:
The authors would like to express thanks to Ko Da Pharmaceutical Co. and Néctar Valley Biopharma Inc. (Tao-Yuan, Taiwan) for in part financial supports.
PY - 2012/6/15
Y1 - 2012/6/15
N2 - The tyrosinase inhibitory and antioxidant activities of four nicotinic acid derivatives, namely, nicotinamide, methyl nicotinate, nicotinic acid hydroxamate (NAH), N-methyl nicotinic acid hydroxamate (NAH-M), and kojic acid, were studied. The tyrosinase inhibitory activity was found to follow the trend: NAH > kojic acid > NAH-M > methyl nicotinate > nicotinamide. The concentrations of half-inhibition (IC 50) of NAH against monophenolase and diphenolase activity were 2 and 1 μM, respectively; the inhibition mode was a mixed-type in the former and an uncompetitive type in the latter. In the antioxidant activity assays, NAH and NAH-M, but not nicotinamide or methyl nicotinate, showed dose-dependent DPPH radical scavenging activity, and their corresponding IC 50 values were 65.81 and 125 μM, respectively. NAH and NAH-M also showed hydroxyl radical scavenging activity and anti-low-density-lipoprotein peroxidation. These results indicate that NAH and NAH-M have the potential to be useful in cosmetics or food processing, and therefore, they should be investigated further.
AB - The tyrosinase inhibitory and antioxidant activities of four nicotinic acid derivatives, namely, nicotinamide, methyl nicotinate, nicotinic acid hydroxamate (NAH), N-methyl nicotinic acid hydroxamate (NAH-M), and kojic acid, were studied. The tyrosinase inhibitory activity was found to follow the trend: NAH > kojic acid > NAH-M > methyl nicotinate > nicotinamide. The concentrations of half-inhibition (IC 50) of NAH against monophenolase and diphenolase activity were 2 and 1 μM, respectively; the inhibition mode was a mixed-type in the former and an uncompetitive type in the latter. In the antioxidant activity assays, NAH and NAH-M, but not nicotinamide or methyl nicotinate, showed dose-dependent DPPH radical scavenging activity, and their corresponding IC 50 values were 65.81 and 125 μM, respectively. NAH and NAH-M also showed hydroxyl radical scavenging activity and anti-low-density-lipoprotein peroxidation. These results indicate that NAH and NAH-M have the potential to be useful in cosmetics or food processing, and therefore, they should be investigated further.
KW - Antioxidant activity
KW - Kojic acid
KW - Nicotinic acid hydroxamate (NAH)
KW - Tyrosinase
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U2 - 10.1016/j.foodchem.2011.12.052
DO - 10.1016/j.foodchem.2011.12.052
M3 - Article
AN - SCOPUS:84857065120
SN - 0308-8146
VL - 132
SP - 2074
EP - 2080
JO - Food Chemistry
JF - Food Chemistry
IS - 4
ER -