BACKGROUND AND PURPOSE - : Brain enhancement on contrast-enhanced T1-weighted imaging (CET1-WI) after ischemic stroke is generally accepted as an indicator of the blood-brain barrier disruption. However, this phenomenon usually starts to become visible at the subacute phase. The purpose of this study was to evaluate the time-course profiles of K, cerebral blood volume (vp), and CET1-WI with early detection of blood-brain barrier changes on K maps and their role for prediction of subsequent hemorrhagic transformation in acute middle cerebral arterial infarct. METHODS - : Twenty-six patients with acute middle cerebral arterial stroke and early spontaneous reperfusion, whose MR images were obtained at predetermined stroke stages, were included. T2*-based MR perfusion-weighted images were acquired using the first-pass pharmacokinetic model to derive K and vp. Parenchymal enhancement observed on maps of K, vp, and CET1-WI at each stage was compared. Association among these measurements and hemorrhagic transformation was analyzed. RESULTS - : K map showed significantly higher parenchymal enhancement in ischemic parenchyma as compared with that of vp map and CET1-WI at early stroke stages (P

Original languageEnglish
Pages (from-to)1872-1877
Number of pages6
Issue number7
Publication statusPublished - Jul 2013


  • bloodbrain barrier
  • K
  • parenchymal enhancement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing


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