Effects of glutamine supplementation on innate immune response in rats with gut-derived sepsis

Sung Ling Yeh, Yu Ni Lai, Huey Fang Shang, Ming Tsan Lin, Wei Jao Chen

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29 Citations (Scopus)


The present study examined the effect of glutamine (Gln)-enriched diets before sepsis or Gln-containing total parenteral nutrition (TPN) after sepsis, or both, on the phagocytic activity and blood lymphocyte subpopulation in rats with gut-derived sepsis. Rats were assigned to a control group or one of four experimental groups. The control group and groups 1 and 2 were fed a semipurified diet; groups 3 and 4 had part of casein replaced by Gln. After feeding the diets for 10 d, sepsis was induced by caecal ligation and puncture (CLP); TPN was maintained for 3 d after CLP. The control group and groups 1 and 3 were infused with conventional TPN and groups 2 and 4 were supplemented with Gln in the TPN solution. All rats were killed 3 d after CLP or sham operation to examine their immune responses. The results showed that compared with the control group, the phagocytic activities of peritoneal macrophages were enhanced in groups 3 and 4, but not in groups 1 and 2. The proportion of CD3+ cells in group 1 was significantly lower (P+ cell proportion was significantly lower (P+ cells and maintained blood total T lymphocytes in gut-derived sepsis. However, parenteral Gln administration after caecal ligation and puncture had no favourable effects on modulating immune response in septic rats.

Original languageEnglish
Pages (from-to)423-429
Number of pages7
JournalBritish Journal of Nutrition
Issue number3
Publication statusPublished - Mar 2004


  • Glutamine
  • Gut-derived sepsis
  • Lymphocyte subpopulation
  • Phagocytosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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