TY - JOUR
T1 - Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy
AU - Lee, Chen Hsien
AU - Chiu, Wan-Chun
AU - Chen, Soul-Chin
AU - Wu, Chih-Hsiung
AU - Yeh, Sung-Ling
PY - 2005/2/14
Y1 - 2005/2/14
N2 - Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P
AB - Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P
KW - Gastrectomy
KW - Glutamine
KW - Parenteral nutrition
KW - Phagocytosis
KW - Gastrectomy
KW - Glutamine
KW - Parenteral nutrition
KW - Phagocytosis
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U2 - 10.3748/wjg.v11.i6.817
DO - 10.3748/wjg.v11.i6.817
M3 - Article
C2 - 15682473
AN - SCOPUS:14544304548
SN - 1007-9327
VL - 11
SP - 817
EP - 822
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 6
ER -