TY - JOUR
T1 - Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents
AU - Chen, Ya Yen
AU - Chen, Chiao Ming
AU - Chao, Pi Yu
AU - Chang, Tsan J.
AU - Liu, Jen Fang
PY - 2005/1/21
Y1 - 2005/1/21
N2 - Aim: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. Methods: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined. QR represented phase II enzymes, the rest of the enzymes tested represented phase I enzymes. Results: The oxidized frying oil feeding produced a significant increase in phase I and II enzyme systems, including the content of CYP450 and microsomal protein, and the activities of NADPH reductase, EROD, PROD, ANH, AMD and QR in rats (P
AB - Aim: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. Methods: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined. QR represented phase II enzymes, the rest of the enzymes tested represented phase I enzymes. Results: The oxidized frying oil feeding produced a significant increase in phase I and II enzyme systems, including the content of CYP450 and microsomal protein, and the activities of NADPH reductase, EROD, PROD, ANH, AMD and QR in rats (P
KW - Frying oil
KW - Houttuynia cordata thunb
KW - Xenobiotic-metabolizing enzyme system
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U2 - 10.3748/wjg.v11.i3.389
DO - 10.3748/wjg.v11.i3.389
M3 - Article
C2 - 15637750
AN - SCOPUS:12344296369
SN - 1007-9327
VL - 11
SP - 389
EP - 392
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 3
ER -