Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

Yung Kai Lin; Ko Hua Chen; Keng Liang Ou; Min Liu

doi:10.1177/0883911511415390

Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

Yung Kai Lin, Ko Hua Chen, Keng Liang Ou, Min Liu

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.

Original language	English
Pages (from-to)	508-518
Number of pages	11
Journal	Journal of Bioactive and Compatible Polymers
Volume	26
Issue number	5
DOIs	https://doi.org/10.1177/0883911511415390
Publication status	Published - Sept 2011

Keywords

bacterial cellulose
biocompatibility
biodegradability
extracellular matrix
growth factor
hydrogel
wound healing

ASJC Scopus subject areas

Bioengineering
Materials Chemistry
Polymers and Plastics
Biomaterials

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10.1177/0883911511415390

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abstract = "To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.",

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AU - Lin, Yung Kai

AU - Chen, Ko Hua

AU - Ou, Keng Liang

AU - Liu, Min

PY - 2011/9

Y1 - 2011/9

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AB - To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.

KW - bacterial cellulose

KW - biocompatibility

KW - biodegradability

KW - extracellular matrix

KW - growth factor

KW - hydrogel

KW - wound healing

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Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

Abstract

Keywords

ASJC Scopus subject areas

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