Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice

Jui Lung Shen, Tsai Ching Hsu, Yi Chen Chen, Jeng Dong Hsu, Lien Chuan Yang, Fuu Jen Tsai, Cheng Chien Li, Ya Wen Cheng, Chih Yang Huang, Bor Show Tzang

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on high-cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin-like growth factor-1 receptor (IGF-1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)-DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED-DSW and might suggest ED-DSW as an ingredient of cardiovascular health food in some niche markets.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Food Biochemistry
Issue number1
Publication statusPublished - Feb 2012
Externally publishedYes

ASJC Scopus subject areas

  • Food Science
  • Cell Biology
  • Pharmacology
  • Biophysics


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