Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice

Jui Lung Shen; Tsai Ching Hsu; Yi Chen Chen; Jeng Dong Hsu; Lien Chuan Yang; Fuu Jen Tsai; Cheng Chien Li; Ya Wen Cheng; Chih Yang Huang; Bor Show Tzang

doi:10.1111/j.1745-4514.2010.00498.x

Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice

Jui Lung Shen, Tsai Ching Hsu, Yi Chen Chen, Jeng Dong Hsu, Lien Chuan Yang, Fuu Jen Tsai, Cheng Chien Li, Ya Wen Cheng, Chih Yang Huang, Bor Show Tzang

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on high-cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin-like growth factor-1 receptor (IGF-1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)-DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED-DSW and might suggest ED-DSW as an ingredient of cardiovascular health food in some niche markets.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Journal of Food Biochemistry
Volume	36
Issue number	1
DOIs	https://doi.org/10.1111/j.1745-4514.2010.00498.x
Publication status	Published - Feb 2012
Externally published	Yes

ASJC Scopus subject areas

Food Science
Cell Biology
Pharmacology
Biophysics

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10.1111/j.1745-4514.2010.00498.x

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title = "Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice",

abstract = "Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on high-cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin-like growth factor-1 receptor (IGF-1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)-DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED-DSW and might suggest ED-DSW as an ingredient of cardiovascular health food in some niche markets.",

author = "Shen, {Jui Lung} and Hsu, {Tsai Ching} and Chen, {Yi Chen} and Hsu, {Jeng Dong} and Yang, {Lien Chuan} and Tsai, {Fuu Jen} and Li, {Cheng Chien} and Cheng, {Ya Wen} and Huang, {Chih Yang} and Tzang, {Bor Show}",

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doi = "10.1111/j.1745-4514.2010.00498.x",

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AU - Shen, Jui Lung

AU - Hsu, Tsai Ching

AU - Chen, Yi Chen

AU - Hsu, Jeng Dong

AU - Yang, Lien Chuan

AU - Tsai, Fuu Jen

AU - Li, Cheng Chien

AU - Cheng, Ya Wen

AU - Huang, Chih Yang

AU - Tzang, Bor Show

PY - 2012/2

Y1 - 2012/2

N2 - Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on high-cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin-like growth factor-1 receptor (IGF-1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)-DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED-DSW and might suggest ED-DSW as an ingredient of cardiovascular health food in some niche markets.

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Effects of deep-sea water on cardiac abnormality in high-cholesterol dietary mice

Abstract

ASJC Scopus subject areas

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