Effects of concurrent chemoradiotherapy on the metastasis and the mesenchymal transition of bladder urothelial carcinoma cells

Yueh Pan; Ying Chui Hong; Chi Hao Hsiao; Hung Jen Shih; Sheng Hsien Huang; Sheng Chuan Wu; Chin Pao Chang; Shao Chi Chiu; Der Yang Cho; Ping Hsiao Shih

doi:10.21873/anticanres.15309

Effects of concurrent chemoradiotherapy on the metastasis and the mesenchymal transition of bladder urothelial carcinoma cells

Yueh Pan, Ying Chui Hong, Chi Hao Hsiao, Hung Jen Shih, Sheng Hsien Huang, Sheng Chuan Wu, Chin Pao Chang, Shao Chi Chiu, Der Yang Cho, Ping Hsiao Shih

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aim: Cancer stem cells (CSCs) have been suggested playing a crucial role in the tumorigenesis and tumor progression. Clinically, concurrent chemoradiotherapy (CCRT) after transurethral resection of the bladder is the widely accepted treatment option for high-grade bladder urothelial carcinoma (UC); however, a proportion of bladder UC patients still suffer from recurrence and metastasis. In the present study, we investigated the stemness properties of bladder UC cells with respect to various disease stages. The metastatic capability and epithelial–mesenchymal transition (EMT) of the parental cells and the CSC cells of bladder UC

Original language	English
Pages (from-to)	4957-4968
Number of pages	12
Journal	Anticancer Research
Volume	41
Issue number	10
DOIs	https://doi.org/10.21873/anticanres.15309
Publication status	Published - Oct 2021

Keywords

Bladder urothelial carcinoma
Cancer stem cell
Chemoradioresistance
Concurrent chemoradiotherapy
Epithelial–mesenchymal transition

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.15309

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title = "Effects of concurrent chemoradiotherapy on the metastasis and the mesenchymal transition of bladder urothelial carcinoma cells",

abstract = "Background/Aim: Cancer stem cells (CSCs) have been suggested playing a crucial role in the tumorigenesis and tumor progression. Clinically, concurrent chemoradiotherapy (CCRT) after transurethral resection of the bladder is the widely accepted treatment option for high-grade bladder urothelial carcinoma (UC); however, a proportion of bladder UC patients still suffer from recurrence and metastasis. In the present study, we investigated the stemness properties of bladder UC cells with respect to various disease stages. The metastatic capability and epithelial–mesenchymal transition (EMT) of the parental cells and the CSC cells of bladder UC",

keywords = "Bladder urothelial carcinoma, Cancer stem cell, Chemoradioresistance, Concurrent chemoradiotherapy, Epithelial–mesenchymal transition",

author = "Yueh Pan and Hong, {Ying Chui} and Hsiao, {Chi Hao} and Shih, {Hung Jen} and Huang, {Sheng Hsien} and Wu, {Sheng Chuan} and Chang, {Chin Pao} and Chiu, {Shao Chi} and Cho, {Der Yang} and Shih, {Ping Hsiao}",

note = "Funding Information: The present study was supported by grants from the Research Fund of the Department of Medical Research, China Medical University Hospital (grant nos. DMR-107-153 and DMR-CELL-1809) and Taipei Municipal WanFang Hospital (grant no.109-wf-eva-28). We also thanked Ya-Hsu Chiu for technological support. Publisher Copyright: {\textcopyright} 2021 International Institute of Anticancer Research. All rights reserved.",

year = "2021",

month = oct,

doi = "10.21873/anticanres.15309",

language = "English",

volume = "41",

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T1 - Effects of concurrent chemoradiotherapy on the metastasis and the mesenchymal transition of bladder urothelial carcinoma cells

AU - Pan, Yueh

AU - Hong, Ying Chui

AU - Hsiao, Chi Hao

AU - Shih, Hung Jen

AU - Huang, Sheng Hsien

AU - Wu, Sheng Chuan

AU - Chang, Chin Pao

AU - Chiu, Shao Chi

AU - Cho, Der Yang

AU - Shih, Ping Hsiao

N1 - Funding Information: The present study was supported by grants from the Research Fund of the Department of Medical Research, China Medical University Hospital (grant nos. DMR-107-153 and DMR-CELL-1809) and Taipei Municipal WanFang Hospital (grant no.109-wf-eva-28). We also thanked Ya-Hsu Chiu for technological support. Publisher Copyright: © 2021 International Institute of Anticancer Research. All rights reserved.

PY - 2021/10

Y1 - 2021/10

N2 - Background/Aim: Cancer stem cells (CSCs) have been suggested playing a crucial role in the tumorigenesis and tumor progression. Clinically, concurrent chemoradiotherapy (CCRT) after transurethral resection of the bladder is the widely accepted treatment option for high-grade bladder urothelial carcinoma (UC); however, a proportion of bladder UC patients still suffer from recurrence and metastasis. In the present study, we investigated the stemness properties of bladder UC cells with respect to various disease stages. The metastatic capability and epithelial–mesenchymal transition (EMT) of the parental cells and the CSC cells of bladder UC

AB - Background/Aim: Cancer stem cells (CSCs) have been suggested playing a crucial role in the tumorigenesis and tumor progression. Clinically, concurrent chemoradiotherapy (CCRT) after transurethral resection of the bladder is the widely accepted treatment option for high-grade bladder urothelial carcinoma (UC); however, a proportion of bladder UC patients still suffer from recurrence and metastasis. In the present study, we investigated the stemness properties of bladder UC cells with respect to various disease stages. The metastatic capability and epithelial–mesenchymal transition (EMT) of the parental cells and the CSC cells of bladder UC

KW - Bladder urothelial carcinoma

KW - Cancer stem cell

KW - Chemoradioresistance

KW - Concurrent chemoradiotherapy

KW - Epithelial–mesenchymal transition

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Effects of concurrent chemoradiotherapy on the metastasis and the mesenchymal transition of bladder urothelial carcinoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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