Effects of cocaine on human nasal mucosa

S. H. Wang; H. W. Wang; J. Y. Wang

doi:10.1007/BF00171534

Effects of cocaine on human nasal mucosa

S. H. Wang, H. W. Wang, J. Y. Wang

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Archives of Oto-Rhino-Laryngology
Volume	250
Issue number	4
DOIs	https://doi.org/10.1007/BF00171534
Publication status	Published - Jul 1993
Externally published	Yes

Keywords

Cocaine
Human nasal mucosa
Sympathetic functions

ASJC Scopus subject areas

Otorhinolaryngology

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10.1007/BF00171534

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AU - Wang, H. W.

AU - Wang, J. Y.

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N2 - The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.

AB - The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.

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KW - Human nasal mucosa

KW - Sympathetic functions

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Effects of cocaine on human nasal mucosa

Abstract

Keywords

ASJC Scopus subject areas

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