Abstract
Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.
| Original language | English |
|---|---|
| Pages (from-to) | 933-935 |
| Number of pages | 3 |
| Journal | Journal of the Pakistan Medical Association |
| Volume | 67 |
| Issue number | 6 |
| Publication status | Published - Jan 1 2017 |
| Externally published | Yes |
Keywords
- Chronic exposure
- Formaldehyde (FA)
- Mice
- Micronucleus
ASJC Scopus subject areas
- General Medicine