Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

Faizul Hasan; Hsiao Yean Chiu; Eisner Salamanca; Edi S. Ridwan; Bayu S. Wiratama; Hendrik S. Budi

doi:10.1055/s-0042-1753470

Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

Faizul Hasan, Hsiao Yean Chiu, Eisner Salamanca, Edi S. Ridwan, Bayu S. Wiratama, Hendrik S. Budi

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.

Original language	English
Journal	European Journal of Dentistry
DOIs	https://doi.org/10.1055/s-0042-1753470
Publication status	Accepted/In press - 2022

Keywords

cycle threshold
infectious disease
mouthwash
oral health
viral load

ASJC Scopus subject areas

General Dentistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1055/s-0042-1753470

Cite this

@article{1691df2b29fa46a7a33932546eddf457,

title = "Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis",

abstract = "The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.",

keywords = "cycle threshold, infectious disease, mouthwash, oral health, viral load",

author = "Faizul Hasan and Chiu, {Hsiao Yean} and Eisner Salamanca and Ridwan, {Edi S.} and Wiratama, {Bayu S.} and Budi, {Hendrik S.}",

note = "Publisher Copyright: {\textcopyright} 2022. The Author(s).",

year = "2022",

doi = "10.1055/s-0042-1753470",

language = "English",

journal = "European Journal of Dentistry",

issn = "1305-7456",

publisher = "Dental Investigations Society",

}

TY - JOUR

T1 - Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load

T2 - A Systematic Review and Meta-analysis

AU - Hasan, Faizul

AU - Chiu, Hsiao Yean

AU - Salamanca, Eisner

AU - Ridwan, Edi S.

AU - Wiratama, Bayu S.

AU - Budi, Hendrik S.

PY - 2022

Y1 - 2022

N2 - The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.

AB - The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results (p < 0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.

KW - cycle threshold

KW - infectious disease

KW - mouthwash

KW - oral health

KW - viral load

UR - http://www.scopus.com/inward/record.url?scp=85138162487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85138162487&partnerID=8YFLogxK

U2 - 10.1055/s-0042-1753470

DO - 10.1055/s-0042-1753470

M3 - Review article

AN - SCOPUS:85138162487

SN - 1305-7456

JO - European Journal of Dentistry

JF - European Journal of Dentistry

ER -

Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this