Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults

Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.