TY - JOUR
T1 - Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults
AU - Shih, Kuang Chung
AU - Janckila, Anthony J.
AU - Lee, Wei Jei
AU - Chou, Yu Ching
AU - Huang, Chun Jui
AU - Kwok, Ching Fai
AU - Ho, Low Tone
AU - Chao, Tsu Yi
N1 - Publisher Copyright:
© 2015.
PY - 2016/1/30
Y1 - 2016/1/30
N2 - Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
AB - Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
KW - Bariatric surgery
KW - Diabetes mellitus
KW - Inflammatory cytokine
KW - Insulin resistance
KW - Metabolic syndrome
KW - Tartrate-resistant acid phosphatase 5a
UR - https://www.scopus.com/pages/publications/84951750251
UR - https://www.scopus.com/inward/citedby.url?scp=84951750251&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2015.11.004
DO - 10.1016/j.cca.2015.11.004
M3 - Article
C2 - 26552040
AN - SCOPUS:84951750251
SN - 0009-8981
VL - 453
SP - 197
EP - 202
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -
