@article{fc3e348709ec495ca51701bd105c4ecc,
title = "Effects of B cell depletion on T cell allogeneic Immune responses: A strategy to reduce allogeneic sensitization",
abstract = "Background: B cell depletion has been employed to treat antibody-mediated organ transplantation rejection, although the effects on cellular immune responses have not been extensively investigated. Methods: A model of B cell depletion used SCID/beige mice reconstituted with BALB/c splenocytes either depleted of B cells (BD) or not (BN). BD and B/N mice received C57BL/6 skin grafts and were sacrificed after 6 weeks (BD-S6 and BN-S6). Results: Recall proliferative responses of BD-S6 splenocytes to C57BL/6 were significantly reduced compared to BN-S6, and central memory T cells' proportions (CD4+CD44+CD62L+ or CD8+CD44+CD62L+) were significantly decreased in BD-S6 spleens. Recall IFN-γ production by BD-S6 splenocytes was significantly reduced compared to BN-S6 splenocytes (p = 0.0028). Survival times of C57BL/6 heart grafts were significantly longer in SCID/beige mice reconstituted with BD-S6 splenocytes (8.5 ± 1.1 days) than for SCID/beige reconstituted with BN-S6 splenocytes (6.0 ± 1.1 days; p = 0.0006). Under cyclosporine therapy, C57BL/6 heart survival was significantly longer for SCID/beige reconstituted with BD-S6 splenocytes (17.5 ± 6.4 days) than those reconstituted with BN-S6 splenocytes (6.2 ± 1.5 days; p < 0.0001). Conclusion: B cell depletion during allogeneic sensitization decreased memory T cells and recalls IFN-γ production and reduced second-set allograft rejection. {\textcopyright} 2009 Elsevier B.V. All rights reserved.",
keywords = "Allogeneic sensitization, B cell depletion, Memory T cells, CD4 antigen, CD8 antigen, cyclosporin, gamma interferon, Hermes antigen, L selectin, alloimmunity, animal cell, animal experiment, animal model, animal tissue, article, B lymphocyte, cardiac graft rejection, cell proliferation, cellular immunity, controlled study, cytokine production, female, graft survival, heart graft, memory T lymphocyte, mouse, nonhuman, priority journal, skin graft, spleen cell, survival time, T lymphocyte, Animals, Antigens, CD, B-Lymphocytes, Cell Proliferation, Graft Rejection, Immunologic Memory, Immunosuppression, Interferon-gamma, Lymphocyte Depletion, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, SCID, Skin Transplantation, T-Lymphocytes, Transplantation Chimera, Transplantation Conditioning",
author = "Meng-Kun Tsai and Hsiung-Fei Chien and Mei-Ching Tzeng and Po-Huang Lee",
note = "被引用次數：2 Export Date: 16 March 2016 CODEN: TRIME 通訊地址: Lee, P.-H.; Department of Surgery, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan; 電子郵件： pohuang1115@ntu.edu.tw 化學物質/CAS: L selectin, 126880-86-2; cyclosporin, 79217-60-0; gamma interferon, 82115-62-6; Antigens, CD; Interferon-gamma, 82115-62-6 參考文獻: Genberg, H., Kumlien, G., Wennberg, L., Gerg, U., Tyden, G., ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a 3-year follow-up (2008) Transplantation, 85, pp. 1745-1754; Faguer, S., Kamar, N., Guilbeaud-Grugier, C., Rituximab therapy for acute humoral rejection after kidney transplantation (2007) Transplantation, 83, pp. 1277-1280; Terasaki, P.I., Ozawa, M., Predicting kidney graft failure by HLA antibodies: a prospective trial (2004) Am J Transplant, 4, pp. 438-443; Billing, H., Reiger, S., Ovens, J., Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplantation recipients (2008) Transplantation, 86, pp. 1214-1221; Noorchashm, H., Reed, A.J., Rostami, S.Y., B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection (2006) J Immunol, 177, pp. 7715-7722; Silveira, P.A., Johnson, E., Chapman, H.D., The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors (2002) Eur J Immunol, 32, pp. 3657-3666; Bouasziz, J., Yanaba, K., Venturi, G.M., Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice (2007) PNAS, 104, pp. 20,878-20,883; Li, Y., Chen, F., Putt, M., B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice (2008) J Immunol, 181, pp. 2961-2972; Chan OT, Hannum LG, Haberman AM, Madaio MP, Shlomchik MJ. 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year = "2009",
doi = "10.1016/j.trim.2009.06.006",
language = "English",
volume = "21",
pages = "215--220",
journal = "Transplant Immunology",
issn = "0966-3274",
publisher = "Elsevier",
number = "4",
}