TY - JOUR
T1 - Effectiveness of Light Therapy in Cognitively Impaired Persons
T2 - A Metaanalysis of Randomized Controlled Trials
AU - Chiu, Huei Ling
AU - Chan, Pi Tuan
AU - Chu, Hsin
AU - Hsiao, Shu Tai Sheen
AU - Liu, Doresses
AU - Lin, Chueh Ho
AU - Chou, Kuei Ru
N1 - Publisher Copyright:
© 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society
PY - 2017/10
Y1 - 2017/10
N2 - Objectives: To explore the effects of light therapy on behavioral disturbances (BDs), sleep quality, and depression. Design: Meta-analysis of randomized controlled trials. Setting: PubMed, Cochrane Library, Medline, EMBASE, Web of Science, and clinicaltrials.gov of selected randomized controlled trials and previous systematic reviews were searched. Participants: Cognitively impaired persons. Measurements: Information was extracted on study characteristics, quality assessment, and outcomes. Outcome measures included BDs, sleep quality, and depression. Results: Nine randomized controlled trials were examined. The results showed that light therapy has a moderate effect on BD (g = −0.61) and depression (g = −0.58) and a small effect on total sleep time at night (g = 0.25). Subgroup analysis indicated that a light intensity of 2,500 lux or greater has a greater effect on depression than an intensity of less than 2,500 lux (P =.03), and the low risk of bias in blinding was superior to the RCTs deemed to be of high or unclear risk of bias in blinding in terms of BD (P =.02). Conclusion: Light therapy can relieve BD, improve sleep quality, and alleviate symptoms of depression for cognitively impaired persons.
AB - Objectives: To explore the effects of light therapy on behavioral disturbances (BDs), sleep quality, and depression. Design: Meta-analysis of randomized controlled trials. Setting: PubMed, Cochrane Library, Medline, EMBASE, Web of Science, and clinicaltrials.gov of selected randomized controlled trials and previous systematic reviews were searched. Participants: Cognitively impaired persons. Measurements: Information was extracted on study characteristics, quality assessment, and outcomes. Outcome measures included BDs, sleep quality, and depression. Results: Nine randomized controlled trials were examined. The results showed that light therapy has a moderate effect on BD (g = −0.61) and depression (g = −0.58) and a small effect on total sleep time at night (g = 0.25). Subgroup analysis indicated that a light intensity of 2,500 lux or greater has a greater effect on depression than an intensity of less than 2,500 lux (P =.03), and the low risk of bias in blinding was superior to the RCTs deemed to be of high or unclear risk of bias in blinding in terms of BD (P =.02). Conclusion: Light therapy can relieve BD, improve sleep quality, and alleviate symptoms of depression for cognitively impaired persons.
KW - behavioral disturbance
KW - cognitively impaired
KW - depression
KW - light therapy
KW - sleep quality
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U2 - 10.1111/jgs.14990
DO - 10.1111/jgs.14990
M3 - Article
C2 - 28734045
AN - SCOPUS:85031492299
SN - 0002-8614
VL - 65
SP - 2227
EP - 2234
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 10
ER -