Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models

Kwang Poo Chang; Dennis K.P. Ng; Chia Kwung Fan; Ramesh B. Batchu; Bala K. Kolli

doi:10.21926/obm.genet.2001103

Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models

Kwang Poo Chang, Dennis K.P. Ng, Chia Kwung Fan, Ramesh B. Batchu, Bala K. Kolli

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines for immune-prophylaxis and –therapy. We have begun to explore the utility of these Leishmania for immunization against tumors in experimental mouse models.

Original language	English
Article number	103
Journal	OBM Genetics
Volume	4
Issue number	1
DOIs	https://doi.org/10.21926/obm.genet.2001103
Publication status	Published - May 2020

Keywords

immunotherapy
Leishmania
photodyanmic inactivation
transgenics
tumor
vaccine delivery

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21926/obm.genet.2001103

Cite this

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title = "Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models",

abstract = "The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines for immune-prophylaxis and –therapy. We have begun to explore the utility of these Leishmania for immunization against tumors in experimental mouse models.",

keywords = "immunotherapy, Leishmania, photodyanmic inactivation, transgenics, tumor, vaccine delivery",

author = "Chang, {Kwang Poo} and Ng, {Dennis K.P.} and Fan, {Chia Kwung} and Batchu, {Ramesh B.} and Kolli, {Bala K.}",

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doi = "10.21926/obm.genet.2001103",

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AU - Chang, Kwang Poo

AU - Ng, Dennis K.P.

AU - Fan, Chia Kwung

AU - Batchu, Ramesh B.

AU - Kolli, Bala K.

PY - 2020/5

Y1 - 2020/5

N2 - The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines for immune-prophylaxis and –therapy. We have begun to explore the utility of these Leishmania for immunization against tumors in experimental mouse models.

AB - The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines for immune-prophylaxis and –therapy. We have begun to explore the utility of these Leishmania for immunization against tumors in experimental mouse models.

KW - immunotherapy

KW - Leishmania

KW - photodyanmic inactivation

KW - transgenics

KW - tumor

KW - vaccine delivery

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Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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