Abstract
• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | International Eye Science |
| Volume | 7 |
| Issue number | 1 |
| Publication status | Published - Feb 2007 |
Keywords
- Age-related macular degeneration
- Blood flow
- Choroid
- Neovascularization
- Z,E-butylidedephthalide
ASJC Scopus subject areas
- Ophthalmology