Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Chi ieong Lau, Mu N. Liu, Kae Chwen Chang, Anna Chang, Chyi Huey Bai, Ching Shiang Tseng, Vincent Walsh, Han Cheng Wang

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

Original languageEnglish
Pages (from-to)1237-1243
Number of pages7
JournalCNS Neuroscience and Therapeutics
Issue number11
Publication statusPublished - Nov 1 2019


  • inhibitory control
  • memory
  • Parkinson's disease
  • tDCS

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)


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