TY - JOUR
T1 - Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
AU - Nepali, Kunal
AU - Kadian, Kanika
AU - Ojha, Ritu
AU - Dhiman, Rajni
AU - Garg, Atul
AU - Singh, Gagandip
AU - Buddhiraja, Abhishek
AU - Bedi, Preet Mohinder Singh
AU - Dhar, Kanaya Lal
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C 6-C 3-C 6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.
AB - Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C 6-C 3-C 6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.
KW - Cell lines
KW - Chalcones
KW - Cytotoxic
KW - Pyrazole
UR - http://www.scopus.com/inward/record.url?scp=84866374072&partnerID=8YFLogxK
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U2 - 10.1007/s00044-011-9824-9
DO - 10.1007/s00044-011-9824-9
M3 - Article
AN - SCOPUS:84866374072
SN - 1054-2523
VL - 21
SP - 2990
EP - 2997
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
IS - 10
ER -
