Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Tsung Te Chung; Chao Bin Yeh; Yi Ching Li; Shih Chi Su; Ming Hsien Chien; Shun Fa Yang; Yi Hsien Hsieh

doi:10.1371/journal.pone.0033517

Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Tsung Te Chung, Chao Bin Yeh, Yi Ching Li, Shih Chi Su, Ming Hsien Chien, Shun Fa Yang, Yi Hsien Hsieh

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Abstract

Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

Original language	English
Article number	e33517
Journal	PLoS ONE
Volume	7
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0033517
Publication status	Published - Mar 12 2012

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title = "Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features",

abstract = "Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.",

author = "Chung, {Tsung Te} and Yeh, {Chao Bin} and Li, {Yi Ching} and Su, {Shih Chi} and Chien, {Ming Hsien} and Yang, {Shun Fa} and Hsieh, {Yi Hsien}",

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T1 - Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

AU - Chung, Tsung Te

AU - Yeh, Chao Bin

AU - Li, Yi Ching

AU - Su, Shih Chi

AU - Chien, Ming Hsien

AU - Yang, Shun Fa

AU - Hsieh, Yi Hsien

PY - 2012/3/12

Y1 - 2012/3/12

N2 - Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

AB - Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

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Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Abstract

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