Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes

W. C V Yang; S. C. Chang

Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The effect of intact proteoglycan as a material for supporting the cell growth and tissue regeneration was discussed. The efficacy of proteoglycan on the regulation of cell proliferation and differentiation was evaluated by introducing the intact proteoglycan instead of using the GAG or core protein alone in an in vitro cultural system. The results indicated that proteoglycans could induce the differentiation of ATDC5 cells to chondrocytes. It was found that both heparan sulfate proteoglycan (CS/DSPG) could enhance the induced differentiation of ATDC5 cells to chondrocytes by insulin. The dual effect of proteoglycan showed its potential to be used in a newly developed bio-mimic material for cartilage repair and regeneration.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Pages	1009
Number of pages	1
Publication status	Published - 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004

Publication series

Name	Transactions - 7th World Biomaterials Congress

Other

Other	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	5/17/04 → 5/21/04

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes",

abstract = "The effect of intact proteoglycan as a material for supporting the cell growth and tissue regeneration was discussed. The efficacy of proteoglycan on the regulation of cell proliferation and differentiation was evaluated by introducing the intact proteoglycan instead of using the GAG or core protein alone in an in vitro cultural system. The results indicated that proteoglycans could induce the differentiation of ATDC5 cells to chondrocytes. It was found that both heparan sulfate proteoglycan (CS/DSPG) could enhance the induced differentiation of ATDC5 cells to chondrocytes by insulin. The dual effect of proteoglycan showed its potential to be used in a newly developed bio-mimic material for cartilage repair and regeneration.",

author = "Yang, {W. C V} and Chang, {S. C.}",

year = "2004",

language = "English",

isbn = "1877040193",

series = "Transactions - 7th World Biomaterials Congress",

pages = "1009",

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note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

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T1 - Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes

AU - Yang, W. C V

AU - Chang, S. C.

PY - 2004

Y1 - 2004

N2 - The effect of intact proteoglycan as a material for supporting the cell growth and tissue regeneration was discussed. The efficacy of proteoglycan on the regulation of cell proliferation and differentiation was evaluated by introducing the intact proteoglycan instead of using the GAG or core protein alone in an in vitro cultural system. The results indicated that proteoglycans could induce the differentiation of ATDC5 cells to chondrocytes. It was found that both heparan sulfate proteoglycan (CS/DSPG) could enhance the induced differentiation of ATDC5 cells to chondrocytes by insulin. The dual effect of proteoglycan showed its potential to be used in a newly developed bio-mimic material for cartilage repair and regeneration.

AB - The effect of intact proteoglycan as a material for supporting the cell growth and tissue regeneration was discussed. The efficacy of proteoglycan on the regulation of cell proliferation and differentiation was evaluated by introducing the intact proteoglycan instead of using the GAG or core protein alone in an in vitro cultural system. The results indicated that proteoglycans could induce the differentiation of ATDC5 cells to chondrocytes. It was found that both heparan sulfate proteoglycan (CS/DSPG) could enhance the induced differentiation of ATDC5 cells to chondrocytes by insulin. The dual effect of proteoglycan showed its potential to be used in a newly developed bio-mimic material for cartilage repair and regeneration.

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M3 - Conference contribution

AN - SCOPUS:13844256614

SN - 1877040193

SN - 9781877040191

T3 - Transactions - 7th World Biomaterials Congress

SP - 1009

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes

Abstract

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