Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh; Deni Taleski; Brendan L. Wilkinson; Lakshmi C. Wijeyewickrem; Ty E. Adams; Robert N. Pike; Richard J. Payne

doi:10.1039/c1cc14773k

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh
, Deni Taleski
, Brendan L. Wilkinson
, Lakshmi C. Wijeyewickrem
, Ty E. Adams
, Robert N. Pike
, Richard J. Payne

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Original language	English
Pages (from-to)	1547-1549
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	10
DOIs	https://doi.org/10.1039/c1cc14773k
Publication status	Published - Jan 11 2012
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc14773k

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title = "Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin",

abstract = "Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.",

author = "Hsieh, \{Yves S.Y.\} and Deni Taleski and Wilkinson, \{Brendan L.\} and Wijeyewickrem, \{Lakshmi C.\} and Adams, \{Ty E.\} and Pike, \{Robert N.\} and Payne, \{Richard J.\}",

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language = "English",

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T1 - Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

AU - Hsieh, Yves S.Y.

AU - Taleski, Deni

AU - Wilkinson, Brendan L.

AU - Wijeyewickrem, Lakshmi C.

AU - Adams, Ty E.

AU - Pike, Robert N.

AU - Payne, Richard J.

PY - 2012/1/11

Y1 - 2012/1/11

N2 - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

AB - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

UR - https://www.scopus.com/pages/publications/84855710913

UR - https://www.scopus.com/pages/publications/84855710913#tab=citedBy

U2 - 10.1039/c1cc14773k

DO - 10.1039/c1cc14773k

M3 - Article

C2 - 22109100

AN - SCOPUS:84855710913

SN - 1359-7345

VL - 48

SP - 1547

EP - 1549

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Abstract

ASJC Scopus subject areas

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