Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh; Deni Taleski; Brendan L. Wilkinson; Lakshmi C. Wijeyewickrem; Ty E. Adams; Robert N. Pike; Richard J. Payne

doi:10.1039/c1cc14773k

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrem, Ty E. Adams, Robert N. Pike, Richard J. Payne

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Original language	English
Pages (from-to)	1547-1549
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	10
DOIs	https://doi.org/10.1039/c1cc14773k
Publication status	Published - Jan 11 2012
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc14773k

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title = "Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin",

abstract = "Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.",

author = "Hsieh, {Yves S.Y.} and Deni Taleski and Wilkinson, {Brendan L.} and Wijeyewickrem, {Lakshmi C.} and Adams, {Ty E.} and Pike, {Robert N.} and Payne, {Richard J.}",

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language = "English",

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T1 - Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

AU - Hsieh, Yves S.Y.

AU - Taleski, Deni

AU - Wilkinson, Brendan L.

AU - Wijeyewickrem, Lakshmi C.

AU - Adams, Ty E.

AU - Pike, Robert N.

AU - Payne, Richard J.

PY - 2012/1/11

Y1 - 2012/1/11

N2 - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

AB - Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

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U2 - 10.1039/c1cc14773k

DO - 10.1039/c1cc14773k

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JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Abstract

ASJC Scopus subject areas

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