Abstract
Objectives: Our previous studies showed that the biodegradation rate of cross-linked porcine dermal collagen membrane (PDCM) could be retarded without changing its biocompatible character. The purpose of this study was to assay the humoral immune response of PDCM reconstitute with glutaraldehyde (GA) and observe their surface architectures. Methods: PDCM reconstituted with GA (0, 0.01, 0.05, and 3%) was implanted in 30 Sprague-Dawley rats. Sample sera were collected 3, 6, and 9 weeks after surgery and assayed with ELISA. The architectures of PDCMs were observed under SEM (100×). Results: The study showed that non cross-linked PDCM induced the highest immune response than any other cross-linked PDCMs (by optical density (OD) values, P
Original language | English |
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Pages (from-to) | 305-311 |
Number of pages | 7 |
Journal | Archives of Oral Biology |
Volume | 49 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2004 |
Keywords
- ELISA
- Glutaraldehyde crosslinking
- Immunogenicity
- PDCM
ASJC Scopus subject areas
- Dentistry(all)