Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model

Yi No Wu; Chun Hou Liao; Kuo Chiang Chen; Shih Ping Liu; Han-Sun Chiang

doi:10.1016/j.urology.2015.01.026

Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model

Yi No Wu, Chun Hou Liao, Kuo Chiang Chen, Shih Ping Liu, Han-Sun Chiang

Taipei Medical University Hospital

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Objective To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Methods Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Results Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P

Original language	English
Article number	19053
Pages (from-to)	1214.e7-1214.e15
Journal	Urology
Volume	85
Issue number	5
DOIs	https://doi.org/10.1016/j.urology.2015.01.026
Publication status	Published - May 1 2015

ASJC Scopus subject areas

Urology

Access to Document

10.1016/j.urology.2015.01.026

Cite this

@article{8e8bccb8e4d346b4b013d903cc798640,

title = "Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model",

abstract = "Objective To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Methods Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Results Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P ",

author = "Wu, {Yi No} and Liao, {Chun Hou} and Chen, {Kuo Chiang} and Liu, {Shih Ping} and Han-Sun Chiang",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.urology.2015.01.026",

language = "English",

volume = "85",

pages = "1214.e7--1214.e15",

journal = "Urology",

issn = "0090-4295",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model

AU - Wu, Yi No

AU - Liao, Chun Hou

AU - Chen, Kuo Chiang

AU - Liu, Shih Ping

AU - Chiang, Han-Sun

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Methods Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Results Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P

AB - Objective To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Methods Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Results Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P

UR - http://www.scopus.com/inward/record.url?scp=84937820686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937820686&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2015.01.026

DO - 10.1016/j.urology.2015.01.026

M3 - Article

SN - 0090-4295

VL - 85

SP - 1214.e7-1214.e15

JO - Urology

JF - Urology

IS - 5

M1 - 19053

ER -

Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this