Effect of electrical discharging on formation of nanoporous biocompatible layer on Ti-6Al-4V alloys

Tzu Sen Yang, Mao Suan Huang, Mao Sheng Wang, Ming Hong Lin, Meng Yuan Tsai, Pei Yi Wang Wang

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


PURPOSE:: In this study, the electrical discharge machining (EDM) was formed on the surface of the Ti-6Al-4V (Ti64) specimen. MATERIALS:: The properties of adhesion and proliferation of MG-63 cells were evaluated the interactions between the EDM-treated layer and cells. RESULTS:: The incorporation of oxygen roughened the EDM-treated specimen surface on a microscale, where the nanoscale pores were superimposed. The EDM-treated layer, which can generate the thick anatase TiO2 on the Ti64 surface, afforded a cytocompatible environment. In cell culture, alkaline phosphatase activity and osteocalcin can be dramatically enhanced on the EDM-treated surfaces when compared with the untreated surface. In addition, the increase in peak currents to the EDM functionalization led to enhancement of multiple osteoblast functions. CONCLUSIONS:: This study reveals that the chemistry and crystallinity of the EDM-treated layer played important roles in affecting osteoblastic responses to the specimens, which provided insight into the development of new biomedical implant surfaces.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalImplant Dentistry
Issue number4
Publication statusPublished - Aug 2013


  • MG-63 cells
  • surface modification
  • x-ray photoelectron spectroscopy

ASJC Scopus subject areas

  • Oral Surgery


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