Effect of curcumin supplementation on physiological fatigue and physical performance in mice

Wen Ching Huang, Wan Chun Chiu, Hsiao Li Chuang, Deh Wei Tang, Zon Min Lee, Wei Li, Fu An Chen, Chi Chang Huang

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)


Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

Original languageEnglish
Pages (from-to)905-921
Number of pages17
Issue number2
Publication statusPublished - Jan 30 2015


  • Ammonia
  • Anti-fatigue
  • Blood urea nitrogen
  • Creatine kinase
  • Endurance
  • Forelimb grip strength
  • Lactate

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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