TY - JOUR
T1 - Effect of Calcium Silicate and β-Tricalcium Phosphate Reinforcement on the Mechanical–Biological Properties of Freeze-Dried Collagen Composite Scaffolds for Bone Tissue Engineering Applications
AU - Animut, Temesgen Yiber
AU - Ningsih, Henni Setia
AU - Shih, Hsueh Huan
AU - Wu, Meng Huang
AU - Shih, Shao Ju
N1 - Funding Information:
This research and APC was funded by National Science and Technology Council of Taiwan (grant number of NSTC 108-2923-E-011-007-MY3 and NSTC 111-2221-E-011-117) and for the Taipei Medical University/National Taiwan University of Science and Technology cross-university collaboration project (under Grant TMU-NTUST-111-10).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - The development of a collagen-based composite scaffold to repair damaged bone is one of many important issues in tissue engineering. In this study, pure collagen, collagen/β-tricalcium phosphate (β-TCP), collagen/calcium silicate (CS), and collagen/β-TCP/CS scaffolds were fabricated using the freeze-drying method. The phase compositions, microstructures, and mechanical properties were characterized using X-ray diffraction, scanning electron microscopy, and a universal testing machine, respectively. In addition, cell viability was evaluated using an MTT assay. Finally, the correlations between the density, mechanical properties, and biodegradation behaviors of pore size distributions were discussed.
AB - The development of a collagen-based composite scaffold to repair damaged bone is one of many important issues in tissue engineering. In this study, pure collagen, collagen/β-tricalcium phosphate (β-TCP), collagen/calcium silicate (CS), and collagen/β-TCP/CS scaffolds were fabricated using the freeze-drying method. The phase compositions, microstructures, and mechanical properties were characterized using X-ray diffraction, scanning electron microscopy, and a universal testing machine, respectively. In addition, cell viability was evaluated using an MTT assay. Finally, the correlations between the density, mechanical properties, and biodegradation behaviors of pore size distributions were discussed.
KW - calcium silicate
KW - collagen
KW - freeze-drying scaffolds
KW - β-tricalcium phosphate
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U2 - 10.3390/ceramics6010033
DO - 10.3390/ceramics6010033
M3 - Article
AN - SCOPUS:85151126905
SN - 2571-6131
VL - 6
SP - 548
EP - 560
JO - Ceramics
JF - Ceramics
IS - 1
ER -