TY - JOUR
T1 - EBV-associated Burkitt lymphoma in Taiwan is not age-related
AU - Chen, Bo Jung
AU - Chang, Sheng Tsung
AU - Weng, Shih Feng
AU - Huang, Wan Ting
AU - Chu, Pei Yi
AU - Hsieh, Pin Pen
AU - Jung, Yun Chih
AU - Kuo, Chun Chi
AU - Chuang, Yu Ting
AU - Chuang, Shih Sung
N1 - Publisher Copyright:
© 2015 Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. EBER was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs adult), abdominal vs extra-abdominal presentation or overall survival (OS). MYC and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. The concordance rate between myc expression and MYC translocation was 83% (40/48). By univariate analysis, OS was statistically associated with age, with or without chemotherapy, central nervous system (CNS) involvement, CNS prophylaxis and leukemic transformation, but not gender, nodal vs extranodal involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation or radiotherapy. By multivariate analysis, CNS involvement at presentation and administration of chemotherapy were statistically associated with OS.
AB - This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. EBER was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs adult), abdominal vs extra-abdominal presentation or overall survival (OS). MYC and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. The concordance rate between myc expression and MYC translocation was 83% (40/48). By univariate analysis, OS was statistically associated with age, with or without chemotherapy, central nervous system (CNS) involvement, CNS prophylaxis and leukemic transformation, but not gender, nodal vs extranodal involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation or radiotherapy. By multivariate analysis, CNS involvement at presentation and administration of chemotherapy were statistically associated with OS.
KW - Burkitt lymphoma
KW - EBV
KW - Fluorescence in situ hybridization
KW - MYC
KW - Taiwan
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UR - http://www.scopus.com/inward/citedby.url?scp=84945231597&partnerID=8YFLogxK
U2 - 10.3109/10428194.2015.1076928
DO - 10.3109/10428194.2015.1076928
M3 - Article
C2 - 26422188
AN - SCOPUS:84945231597
SN - 1042-8194
VL - 57
SP - 644
EP - 653
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 3
ER -
