TY - JOUR
T1 - Dynamic MRI for tumor enhancement
T2 - An experimental breast cancer model
AU - Leung, Ting-Kai
AU - Huang, Pai Jung
AU - Lee, Chi-Ming
AU - Wu, Chih Hsiung
AU - Chen, Yi Fan
AU - Shen, Li Kuo
AU - Hsiao, Wen Tien
PY - 2013/2
Y1 - 2013/2
N2 - Dynamic contrast-enhanced magnetic resonance imaging (MRI) with post-processing is routinely used for the analysis of tumors. However, although breast MRI has gained broad clinical recognition, the relationship between imaging findings and tumor pathogenesis has yet to be fully elucidated. We grafted tumors on rats, to examine dynamic MRI images of the tumors, using post-processing subtraction with 3D maximum intensity projection (sMIP). We established a preliminary platform for analysis to compare hemodynamic-based images with histopathological findings and to further biomolecular research. This platform could facilitate future research on the mechanisms of breast tumor enhancement using MRI, improvements to MRI analysis and reduction of the false positive rate, and the development of novel drugs and contrast media.
AB - Dynamic contrast-enhanced magnetic resonance imaging (MRI) with post-processing is routinely used for the analysis of tumors. However, although breast MRI has gained broad clinical recognition, the relationship between imaging findings and tumor pathogenesis has yet to be fully elucidated. We grafted tumors on rats, to examine dynamic MRI images of the tumors, using post-processing subtraction with 3D maximum intensity projection (sMIP). We established a preliminary platform for analysis to compare hemodynamic-based images with histopathological findings and to further biomolecular research. This platform could facilitate future research on the mechanisms of breast tumor enhancement using MRI, improvements to MRI analysis and reduction of the false positive rate, and the development of novel drugs and contrast media.
KW - Animal platform
KW - Breast cell line
KW - MRI
KW - Post-processing subtraction with 3D maximum intensity projection
KW - Tumor graft
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U2 - 10.4015/S1016237213500117
DO - 10.4015/S1016237213500117
M3 - Article
AN - SCOPUS:84874163391
SN - 1016-2372
VL - 25
JO - Biomedical Engineering - Applications, Basis and Communications
JF - Biomedical Engineering - Applications, Basis and Communications
IS - 1
M1 - 1350011
ER -
