Dynamic MRI for tumor enhancement: An experimental breast cancer model

Ting-Kai Leung, Pai Jung Huang, Chi-Ming Lee, Chih Hsiung Wu, Yi Fan Chen, Li Kuo Shen, Wen Tien Hsiao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Dynamic contrast-enhanced magnetic resonance imaging (MRI) with post-processing is routinely used for the analysis of tumors. However, although breast MRI has gained broad clinical recognition, the relationship between imaging findings and tumor pathogenesis has yet to be fully elucidated. We grafted tumors on rats, to examine dynamic MRI images of the tumors, using post-processing subtraction with 3D maximum intensity projection (sMIP). We established a preliminary platform for analysis to compare hemodynamic-based images with histopathological findings and to further biomolecular research. This platform could facilitate future research on the mechanisms of breast tumor enhancement using MRI, improvements to MRI analysis and reduction of the false positive rate, and the development of novel drugs and contrast media.

Original languageEnglish
Article number1350011
JournalBiomedical Engineering - Applications, Basis and Communications
Issue number1
Publication statusPublished - Feb 2013


  • Animal platform
  • Breast cell line
  • MRI
  • Post-processing subtraction with 3D maximum intensity projection
  • Tumor graft

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Bioengineering


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