Dynamic changes of matrix metalloproteinase-9 in patients with Klebsiella pneumoniae meningitis

Hung Chin Tsai, Sheng Fu Liu, Kuan Sheng Wu, Yung Ching Liu, Min Hon Shi, Eng Rin Chen, Chuan Min Yen, Susan Shin Jung Lee, Yen Lin Huang, Yao Shen Chen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


To quantitate cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase 9 (MMP-9) in adult patients with Klebsiella pneumoniae meningitis and to correlate levels of MMP-9 with parameters of intrathecal inflammation and analyze the kinetic changes of MMP-9. In a prospective cohort study, levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP-1) concentrations were measured in the CSF of six adult patients with meningitis and 11 controls. MMP-9 and TIMP-1 were detected in all of the six patients at presentation and follow up lumbar puncture. CSF levels of MMP-9 (6.71±7.29 ng/ml) and TIMP-1(454.3±242.9 ng/ml) were higher in patients than in the control group (0.07±0.11 ng/ml and 27.14±39.34 ng/ml, respectively). Levels of MMP-9 correlated with CSF concentrations of protein, cell count and lactate. Repeated lumbar punctures showed that levels of MMP-9 decrease during clinical recovery, although the levels of MMP-9 in the CSF are variable because of the small number of cases. The relative change in gelatin zymography is comparable to the changes of MMP-9 levels found in ELISA. MMP-9 levels in CSF may be a useful tool in follow-up in patients with K. pneumoniae meningitis.

Original languageEnglish
Pages (from-to)247-253
Number of pages7
Issue number4
Publication statusPublished - Aug 2008
Externally publishedYes


  • Gelatin zymography
  • Klebsiella pneumoniae
  • Matrix metalloproteinase 9
  • Meningitis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology


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