Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects

Hao Jui Weng, Quoc Thao Trang Pham, Chia Wei Chang, Tsen Fang Tsai

Research output: Contribution to journalReview articlepeer-review


Pain and itch are both important manifestations of various disorders, such as herpes zoster, atopic dermatitis, and psoriasis. Growing evidence suggests that both sensations have shared mediators, overlapping neural circuitry, and similarities in sensitization processes. In fact, pain and itch coexist in some disorders. Determining pharmaceutical agents and targets for treating pain and itch concurrently is of scientific and clinical relevance. Here we review the neurobiology of pain and itch and discuss the pharmaceutical targets as well as novel compounds effective for the concurrent treatment of these sensations.

Original languageEnglish
Article number892
Issue number7
Publication statusPublished - Jul 2022


  • neuropathy
  • pain
  • pruritus

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery


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